Jon Lansdale is a comic book artist who loses his right hand in a car accident. The hand was not found at the scene of the accident, but it soon returns by itself to follow Jon around, and murder those who anger him.
After being exposed to a bizarre mixture of household chemicals, Pat Kramer begins to shrink. This baffles scientists, makes parenting difficult, warms the hearts of Americans, and captures the attention of a group of people who want to take over the world. This evil group plots to kidnap Pat and perform experiments on her so that they can eventually shrink everyone.